Vfold3D 2.0 offers a new user-friendly approach to the fully automated prediction of RNA 3D structures with given sequences and 2D structures. The method is based on the assembly of A-form helices with loop and/or motif templates, extracted from known RNA 3D structures.

Due to the limitation of the current template library, Vfold3D may give no predictions.

Submit a new job:
(1) Input sequence and 2D structure in dot-bracket format (Use "-" to separate RNA strands for RNA complex systems (up to 10 strands)):

(2) Number of clusters (<=5):

(3) RMSD cut_off ( in ) for clustering (<=10 ):

(4) Job name (alphanumeric characters only):

(5) Your email address (optional, you will receive the results by email, if provided):

References for Vfold3D:

[1] Xu X, Chen S-J. (2017) RNA three-dimensional structure prediction using hierarchical loop template assembly.
[2] Xu X, Zhao P, Chen S-J. (2014) Vfold: a web server for RNA structure and folding thermodynamics prediction. PLoS ONE, 9(9):e107504.
[3] Cao S, Chen S-J. (2011) Physics-based de novo prediction of RNA 3D structures. The Journal of Physical Chemistry B, 115:4216-4226.

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